Assay Detail
ADMET
CHEMBL5232965
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CYP2C9 in human liver microsomes using tolbutamide as substrate by LC-MS/MS analysis
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Tissue | Liver |
| Subcellular | Microsome |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Pyridine based dual binding site aromatase (CYP19A1) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.96 | 6.61 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1109 | SULFAPHENAZOLE | 4.0 | 1 | 6.61 |
| CHEMBL5283822 | — | — | 1 | 5.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1109 | SULFAPHENAZOLE | IC50 | = | 245.0 | nM | 6.61 |
| CHEMBL5283822 | — | IC50 | = | 4900.0 | nM | 5.31 |