Assay Detail
Binding
CHEMBL5234292
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Inhibition of recombinant human MMP1 expressed in Escherichia coli BL21 (DE3) using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate incubated for 20 to 30 mins by fluorescence assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Matrix metalloproteinase-9 (MMP-9) and its inhibitors in cancer: A minireview.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.44 | 8.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5284688 | — | — | 1 | 8.62 |
| CHEMBL333586 | — | — | 1 | 7.66 |
| CHEMBL5283286 | — | — | 1 | 6.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5284688 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL333586 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL5283286 | — | IC50 | = | 944.0 | nM | 6.03 |