Compound Detail
CHEMBL5284688
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Basic Information
| ChEMBL ID | CHEMBL5284688 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | WMYJDFANEQLDGP-UHFFFAOYSA-N |
6
Targets
6
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
356.4
MW (Da)
1.77
ALogP
5
HBA
2
HBD
95.9
PSA (Ų)
0.63
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 6 meas. best 9.3
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Matrix metalloproteinase-9 CHEMBL321 | IC50 | 9.3 | 9.3 | 0.5 | 1 |
| 72 kDa type IV collagenase CHEMBL333 | IC50 | 8.85 | 8.85 | 1.4 | 1 |
| Neutrophil collagenase CHEMBL4588 | IC50 | 8.72 | 8.72 | 1.9 | 1 |
| Interstitial collagenase CHEMBL332 | IC50 | 8.62 | 8.62 | 2.4 | 1 |
| Stromelysin-1 CHEMBL283 | IC50 | 8.48 | 8.48 | 3.3 | 1 |
| Matrilysin CHEMBL4073 | IC50 | 7.75 | 7.75 | 18.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Matrix metalloproteinase-9 | IC50 | = | 0.5 | nM | 9.3 | Inhibition of recombinant human MMP9 using Mca-Pro-Leu-Dpa-Ala-Arg-NH2 as substr... | 32224379 |
| 72 kDa type IV collagenase | IC50 | = | 1.4 | nM | 8.85 | Inhibition of recombinant human full length MMP2 using Mca-Pro-Leu-Dpa-Ala-Arg-N... | 32224379 |
| Neutrophil collagenase | IC50 | = | 1.9 | nM | 8.72 | Inhibition of recombinant human MMP8 using Mca-Pro-Leu-Dpa-Ala-Arg-NH2 as substr... | 32224379 |
| Interstitial collagenase | IC50 | = | 2.4 | nM | 8.62 | Inhibition of recombinant human MMP1 expressed in Escherichia coli BL21 (DE3) us... | 32224379 |
| Stromelysin-1 | IC50 | = | 3.3 | nM | 8.48 | Inhibition of recombinant human MMP3 expressed in Escherichia coli BL21 (DE3) us... | 32224379 |
| Matrilysin | IC50 | = | 18.0 | nM | 7.75 | Inhibition of recombinant human MMP7 using Mca-Pro-Leu-Dpa-Ala-Arg-NH2 as substr... | 32224379 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 32224379 | 10.1016/j.ejmech.2020.112260 | Interstitial collagenase | 1 |
| 32224379 | 10.1016/j.ejmech.2020.112260 | 72 kDa type IV collagenase | 1 |
| 32224379 | 10.1016/j.ejmech.2020.112260 | Stromelysin-1 | 1 |
| 32224379 | 10.1016/j.ejmech.2020.112260 | Matrilysin | 1 |
| 32224379 | 10.1016/j.ejmech.2020.112260 | Neutrophil collagenase | 1 |
| 32224379 | 10.1016/j.ejmech.2020.112260 | Matrix metalloproteinase-9 | 1 |
Data from ChEMBL 36 via Core Engine