Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL5235225

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production preincubated for 0.5 hrs followed by LPS stimulation and measured after 24 hrs by Griess reagent based analysis
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Cell Type RAW264.7
Confidence 1 — Organism
Curated By Autocuration

Target

RAW264.7 (CHEMBL612557)
Type CELL-LINE
Organism Mus musculus

Publication

Anti-inflammatory activity of naturally occuring diarylheptanoids - A review.
Vanucci-Bacqué C, Bedos-Belval F.
Bioorg Med Chem (2021) 31 : 115971 -115971
PubMed 33422907 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 17 4.85 5.54

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5276513 1 5.54
CHEMBL464274 DEHYDROHIRSUTANONOL 1 5.30
CHEMBL330645 PLATYPHYLLENONE 1 5.16
CHEMBL5278765 1 5.09
CHEMBL2346808 1 5.07
CHEMBL5280002 1 5.00
CHEMBL5273900 1 4.98
CHEMBL5288695 1 4.82
CHEMBL598970 ALNUSIDE B 1 4.82
CHEMBL5277499 1 4.81
CHEMBL464363 1 4.70
CHEMBL464570 OREGONIN 1 4.68
CHEMBL5271081 1 4.66
CHEMBL5272523 1 4.66
CHEMBL5272188 1 4.52
CHEMBL455297 HIRSUTANONOL 1 4.52
CHEMBL5282400 1 4.20

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5276513 IC50 = 2900.0 nM 5.54
CHEMBL464274 DEHYDROHIRSUTANONOL IC50 = 5000.0 nM 5.30
CHEMBL330645 PLATYPHYLLENONE IC50 = 6900.0 nM 5.16
CHEMBL5278765 IC50 = 8100.0 nM 5.09
CHEMBL2346808 IC50 = 8600.0 nM 5.07
CHEMBL5280002 IC50 = 10000.0 nM 5.00
CHEMBL5273900 IC50 = 10500.0 nM 4.98
CHEMBL5288695 IC50 = 15200.0 nM 4.82
CHEMBL598970 ALNUSIDE B IC50 = 15200.0 nM 4.82
CHEMBL5277499 IC50 = 15400.0 nM 4.81
CHEMBL464363 IC50 = 20000.0 nM 4.70
CHEMBL464570 OREGONIN IC50 = 21100.0 nM 4.68
CHEMBL5271081 IC50 = 22100.0 nM 4.66
CHEMBL5272523 IC50 = 22000.0 nM 4.66
CHEMBL5272188 IC50 = 30000.0 nM 4.52
CHEMBL455297 HIRSUTANONOL IC50 = 30000.0 nM 4.52
CHEMBL5282400 IC50 = 63000.0 nM 4.20