Assay Detail
Binding
CHEMBL5236743
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of N terminal histidine tagged human recombinant ROCK1 (3 to 543 residues) in HASMC cells incubated for 2 hrs by ELISA method
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HASMC |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Furazans in Medicinal Chemistry.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.19 | 5.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL220241 | GSK-269962A | — | 1 | 5.52 |
| CHEMBL1956071 | — | — | 1 | 5.52 |
| CHEMBL559147 | Y-27632 | — | 1 | 4.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL220241 | GSK-269962A | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL1956071 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL559147 | Y-27632 | IC50 | = | 30000.0 | nM | 4.52 |