Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL5237375

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human CLK1
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Dual specificity protein kinase CLK1 (CHEMBL4224)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Development of Cdc2-like Kinase 2 Inhibitors: Achievements and Future Directions.
Qin Z, Qin L, Feng X, Li Z, Bian J.
J Med Chem (2021) 64 : 13191 -13211
PubMed 34519506 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 26 7.44 9.17

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4531334 T3-CLK 1 9.17
CHEMBL5283453 1 8.96
CHEMBL5286791 1 8.96
CHEMBL4083249 1 8.70
CHEMBL4082113 1 8.15
CHEMBL4754195 1 8.10
CHEMBL5282544 1 7.96
CHEMBL187139 1 7.89
CHEMBL5276465 1 7.77
CHEMBL4283751 1 7.67
CHEMBL3883660 1 7.64
CHEMBL4061526 1 7.55
CHEMBL567331 1 7.43
CHEMBL5287646 1 7.29
CHEMBL1885748 1 7.17
CHEMBL1802358 1 7.15
CHEMBL4796016 1 7.06
CHEMBL4284209 1 7.00
CHEMBL5180549 1 6.95
CHEMBL3589660 1 6.89
CHEMBL3297832 1 6.68
CHEMBL4062218 1 6.52
CHEMBL5290575 1 6.42
CHEMBL603189 POLYANDROCARPAMINE A 1 6.33
CHEMBL4290222 1 6.11
CHEMBL1604618 1 5.82

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4531334 T3-CLK IC50 = 0.67 nM 9.17
CHEMBL5283453 IC50 = 1.1 nM 8.96
CHEMBL5286791 IC50 = 1.1 nM 8.96
CHEMBL4083249 IC50 = 2.0 nM 8.70
CHEMBL4082113 IC50 = 7.0 nM 8.15
CHEMBL4754195 IC50 = 8.0 nM 8.10
CHEMBL5282544 IC50 = 11.0 nM 7.96
CHEMBL187139 IC50 = 13.0 nM 7.89
CHEMBL5276465 IC50 = 17.0 nM 7.77
CHEMBL4283751 IC50 = 21.6 nM 7.67
CHEMBL3883660 IC50 = 23.0 nM 7.64
CHEMBL4061526 IC50 = 28.0 nM 7.55
CHEMBL567331 IC50 = 37.0 nM 7.43
CHEMBL5287646 IC50 = 51.0 nM 7.29
CHEMBL1885748 IC50 = 68.0 nM 7.17
CHEMBL1802358 IC50 = 71.0 nM 7.15
CHEMBL4796016 IC50 = 88.0 nM 7.06
CHEMBL4284209 IC50 = 100.0 nM 7.00
CHEMBL5180549 IC50 = 112.6 nM 6.95
CHEMBL3589660 IC50 = 130.0 nM 6.89
CHEMBL3297832 IC50 = 210.0 nM 6.68
CHEMBL4062218 IC50 = 300.0 nM 6.52
CHEMBL5290575 IC50 = 380.0 nM 6.42
CHEMBL603189 POLYANDROCARPAMINE A IC50 = 470.0 nM 6.33
CHEMBL4290222 IC50 = 786.0 nM 6.11
CHEMBL1604618 IC50 = 1522.0 nM 5.82