Assay Detail
Functional
CHEMBL5238073
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Antiproliferative activity against human NCI-H2228 cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H2228 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design and synthesis of boron-containing ALK inhibitor with favorable in vivo efficacy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.11 | 6.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL601719 | CRIZOTINIB | 4.0 | 1 | 6.36 |
| CHEMBL5271682 | — | — | 1 | 6.28 |
| CHEMBL5268953 | — | — | 1 | 6.21 |
| CHEMBL5266396 | — | — | 1 | 6.21 |
| CHEMBL5269028 | — | — | 1 | 6.16 |
| CHEMBL5291435 | — | — | 1 | 6.08 |
| CHEMBL5286011 | — | — | 1 | 5.95 |
| CHEMBL5283671 | — | — | 1 | 5.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL601719 | CRIZOTINIB | IC50 | = | 437.9 | nM | 6.36 |
| CHEMBL5271682 | — | IC50 | = | 520.3 | nM | 6.28 |
| CHEMBL5268953 | — | IC50 | = | 624.4 | nM | 6.21 |
| CHEMBL5266396 | — | IC50 | = | 617.2 | nM | 6.21 |
| CHEMBL5269028 | — | IC50 | = | 699.1 | nM | 6.16 |
| CHEMBL5291435 | — | IC50 | = | 825.4 | nM | 6.08 |
| CHEMBL5286011 | — | IC50 | = | 1134.2 | nM | 5.95 |
| CHEMBL5283671 | — | IC50 | = | 2551.4 | nM | 5.59 |