Compound Detail
CHEMBL5268953
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Basic Information
| ChEMBL ID | CHEMBL5268953 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | BKJCLHFYGLDIJR-UHFFFAOYSA-N |
2
Targets
4
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
508.8
MW (Da)
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 8.27
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| ALK tyrosine kinase receptor CHEMBL4247 | IC50 | 8.27 | 8.0333 | 5.4 | 3 |
| NCI-H2228 CHEMBL1075536 | IC50 | 6.21 | 6.21 | 624.4 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| ALK tyrosine kinase receptor | IC50 | = | 5.4 | nM | 8.27 | Inhibition of N-terminal GST-tagged human ALK cytoplasmic domain (1058 to 1620 r... | 36332597 |
| ALK tyrosine kinase receptor | IC50 | = | 9.2 | nM | 8.04 | Inhibition of N-terminal GST-tagged human wild type ALK cytoplasmic domain (1058... | 36332597 |
| ALK tyrosine kinase receptor | IC50 | = | 16.4 | nM | 7.79 | Inhibition of N-terminal GST-tagged human ALK cytoplasmic domain (1058 to 1620 r... | 36332597 |
| NCI-H2228 | IC50 | = | 624.4 | nM | 6.21 | Antiproliferative activity against human NCI-H2228 cells assessed as reduction i... | 36332597 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 36332597 | 10.1016/j.bmc.2022.117071 | ALK tyrosine kinase receptor | 3 |
| 36332597 | 10.1016/j.bmc.2022.117071 | NCI-H2228 | 1 |
Data from ChEMBL 36 via Core Engine