Assay Detail
Binding
CHEMBL5240496
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of equine BChE using acetylthiocholine chloride as substrate preincubated for 15 mins followed by substrate addition and measured after 30 mins by DTNB reagent based Ellman's method
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Equus caballus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Multitargeting approaches to cognitive impairment: Synthesis of aryl-alkylpiperazines and assessment at cholinesterases, histamine H<sub>3</sub> and dopamine D<sub>3</sub> receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 4.53 | 6.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL278020 | NEOSTIGMINE | 4.0 | 1 | 6.80 |
| CHEMBL4069293 | — | — | 1 | 4.78 |
| CHEMBL5280702 | — | — | 1 | 4.58 |
| CHEMBL5289654 | — | — | 1 | 4.39 |
| CHEMBL5270151 | — | — | 1 | 4.36 |
| CHEMBL4293814 | — | — | 1 | 4.27 |
| CHEMBL5283987 | — | — | 1 | 4.24 |
| CHEMBL5276899 | — | — | 1 | 4.23 |
| CHEMBL5267271 | — | — | 1 | 4.11 |
| CHEMBL5265920 | — | — | 1 | 4.07 |
| CHEMBL5278711 | — | — | 1 | 4.01 |
| CHEMBL5289468 | — | — | 1 | - |
| CHEMBL5282002 | — | — | 1 | - |
| CHEMBL5276588 | — | — | 1 | - |
| CHEMBL5270288 | — | — | 1 | - |
| CHEMBL5287235 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL278020 | NEOSTIGMINE | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4069293 | — | IC50 | = | 16700.0 | nM | 4.78 |
| CHEMBL5280702 | — | IC50 | = | 26300.0 | nM | 4.58 |
| CHEMBL5289654 | — | IC50 | = | 40700.0 | nM | 4.39 |
| CHEMBL5270151 | — | IC50 | = | 43700.0 | nM | 4.36 |
| CHEMBL4293814 | — | IC50 | = | 53700.0 | nM | 4.27 |
| CHEMBL5283987 | — | IC50 | = | 57500.0 | nM | 4.24 |
| CHEMBL5276899 | — | IC50 | = | 58900.0 | nM | 4.23 |
| CHEMBL5267271 | — | IC50 | = | 78500.0 | nM | 4.11 |
| CHEMBL5265920 | — | IC50 | = | 85100.0 | nM | 4.07 |
| CHEMBL5278711 | — | IC50 | = | 97700.0 | nM | 4.01 |
| CHEMBL5289468 | — | IC50 | - | — | - | |
| CHEMBL5282002 | — | IC50 | - | — | - | |
| CHEMBL5276588 | — | IC50 | - | — | - | |
| CHEMBL5270288 | — | IC50 | - | — | - | |
| CHEMBL5287235 | — | IC50 | - | — | - |