Assay Detail
Functional
CHEMBL5243050
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human THP-1 cells harboring p53 mutation assessed as reduction in cell viability incubated for 72 hrs by CellTiter-Glo assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | THP-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery and Characterization of the Potent and Highly Selective 1,7-Naphthyridine-Based Inhibitors BAY-091 and BAY-297 of the Kinase PIP4K2A.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 4.52 | 4.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5290005 | — | — | 1 | 4.52 |
| CHEMBL4802045 | BAY-091 | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5290005 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL4802045 | BAY-091 | IC50 | > | 30000.0 | nM | - |