Assay Detail
Binding
CHEMBL5243580
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of ovine COX-1
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Ovis aries |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Insights into the medicinal chemistry of heterocycles integrated with a pyrazolo[1,5-<i>a</i>]pyrimidine scaffold.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.23 | 6.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | 6.54 |
| CHEMBL118 | CELECOXIB | 4.0 | 1 | 5.13 |
| CHEMBL5266517 | — | — | 1 | 5.10 |
| CHEMBL5280862 | — | — | 1 | 5.07 |
| CHEMBL5267419 | — | — | 1 | 5.07 |
| CHEMBL5278118 | — | — | 1 | 5.04 |
| CHEMBL5274868 | — | — | 1 | 4.99 |
| CHEMBL5275045 | — | — | 1 | 4.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6 | INDOMETHACIN | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL118 | CELECOXIB | IC50 | = | 7340.0 | nM | 5.13 |
| CHEMBL5266517 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL5280862 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL5267419 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL5278118 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL5274868 | — | IC50 | = | 10200.0 | nM | 4.99 |
| CHEMBL5275045 | — | IC50 | = | 12560.0 | nM | 4.90 |