Assay Detail
Functional
CHEMBL5244572
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Antibacterial activity against wild type Mycobacterium tuberculosis H37Rv assessed as bacterial growth inhibition
8
Total Activities
8
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mycobacterium tuberculosis |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Drug discovery in tuberculosis. New drug targets and antimycobacterial agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| MIC | 5 | - | - |
| IC50 | 2 | 6.00 | 6.34 |
| MIC50 | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL899 | LANSOPRAZOLE SULFIDE | — | 1 | 6.34 |
| CHEMBL480 | LANSOPRAZOLE | 4.0 | 1 | 5.66 |
| CHEMBL1822872 | BTZ-043 | 2.0 | 1 | - |
| CHEMBL3330226 | MACOZINONE | 2.0 | 1 | - |
| CHEMBL4587211 | — | — | 1 | - |
| CHEMBL4460207 | — | — | 1 | - |
| CHEMBL1976041 | — | — | 1 | - |
| CHEMBL3298910 | TELACEBEC | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL899 | LANSOPRAZOLE SULFIDE | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL480 | LANSOPRAZOLE | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL1822872 | BTZ-043 | MIC | = | 0.23 | nM | - |
| CHEMBL3330226 | MACOZINONE | MIC | = | 0.00019 | ug.mL-1 | - |
| CHEMBL4587211 | — | MIC | = | 350.0 | nM | - |
| CHEMBL4460207 | — | MIC | = | 340.0 | nM | - |
| CHEMBL1976041 | — | MIC | = | 3100.0 | nM | - |
| CHEMBL3298910 | TELACEBEC | MIC50 | = | 2.7 | nM | - |