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Assay Detail

CHEMBL5244659

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antitrypanosomal activity against Trypanosoma cruzi Y intracellular trypomastigote transfected in monkey LLC-MK2 cells assessed as inhibition of intracellular trypomastigote viability measured after 24 hrs by Neubauer chamber based analysis
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Trypanosoma cruzi
Cell Type LLC-MK2
Confidence 1 — Organism
Curated By Autocuration

Target

Trypanosoma cruzi (CHEMBL368)
Type ORGANISM
Organism Trypanosoma cruzi

Publication

Current advances in drug discovery for Chagas disease.
Scarim CB, Jornada DH, Chelucci RC, de Almeida L, Dos Santos JL, Chung MC.
Eur J Med Chem (2018) 155 : 824 -838
PubMed 30033393 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 5.84 5.84

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL193804 1 5.84

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL193804 IC50 = 1430.0 nM 5.84