Assay Detail
Functional
CHEMBL5246789
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Antimalarial activity against Plasmodium falciparum K1
44
Total Activities
43
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Exploration of artemisinin derivatives and synthetic peroxides in antimalarial drug discovery research.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 38 | 8.18 | 9.70 |
| EC50 | 5 | 8.30 | 8.62 |
| ED50 | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4637440 | — | — | 1 | 9.70 |
| CHEMBL4648465 | — | — | 1 | 9.30 |
| CHEMBL5266690 | — | — | 1 | 9.07 |
| CHEMBL2387268 | — | — | 1 | 8.96 |
| CHEMBL5275788 | — | — | 1 | 8.95 |
| CHEMBL5283170 | — | — | 1 | 8.75 |
| CHEMBL5289927 | — | — | 1 | 8.68 |
| CHEMBL4646884 | — | — | 1 | 8.62 |
| CHEMBL5182907 | — | — | 1 | 8.52 |
| CHEMBL5282339 | — | — | 1 | 8.51 |
| CHEMBL5286129 | — | — | 1 | 8.50 |
| CHEMBL5290797 | — | — | 1 | 8.46 |
| CHEMBL269671 | ARTEMISININ | 3.0 | 1 | 8.44 |
| CHEMBL5270134 | — | — | 1 | 8.32 |
| CHEMBL5291480 | — | — | 1 | 8.24 |
| CHEMBL3601443 | — | — | 1 | 8.24 |
| CHEMBL5290713 | — | — | 1 | 8.20 |
| CHEMBL5273979 | — | — | 1 | 8.12 |
| CHEMBL566534 | ARTEMETHER | 4.0 | 2 | 8.05 |
| CHEMBL5286757 | — | — | 1 | 7.72 |
| CHEMBL5280728 | — | — | 1 | 7.70 |
| CHEMBL5277211 | — | — | 1 | 7.68 |
| CHEMBL5278609 | — | — | 1 | 7.64 |
| CHEMBL5288216 | — | — | 1 | 7.54 |
| CHEMBL5282979 | — | — | 1 | 7.48 |
| CHEMBL5288233 | — | — | 1 | 7.28 |
| CHEMBL5274018 | — | — | 1 | 7.25 |
| CHEMBL5271497 | — | — | 1 | 7.07 |
| CHEMBL5290306 | — | — | 1 | 6.94 |
| CHEMBL5284941 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4637440 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL4648465 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL5266690 | — | IC50 | = | 0.85 | nM | 9.07 |
| CHEMBL2387268 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL5275788 | — | IC50 | = | 1.12 | nM | 8.95 |
| CHEMBL5283170 | — | IC50 | = | 1.79 | nM | 8.75 |
| CHEMBL5289927 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL4646884 | — | EC50 | = | 2.4 | nM | 8.62 |
| CHEMBL5182907 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL5282339 | — | EC50 | = | 3.1 | nM | 8.51 |
| CHEMBL5286129 | — | IC50 | = | 3.15 | nM | 8.50 |
| CHEMBL5290797 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL269671 | ARTEMISININ | EC50 | = | 3.6 | nM | 8.44 |
| CHEMBL5270134 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL3601443 | — | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL5291480 | — | EC50 | = | 5.8 | nM | 8.24 |
| CHEMBL5290713 | — | IC50 | = | 6.27 | nM | 8.20 |
| CHEMBL5273979 | — | IC50 | = | 7.6 | nM | 8.12 |
| CHEMBL566534 | ARTEMETHER | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL5286757 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL5280728 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL5277211 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL5278609 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL5288216 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL5282979 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL5288233 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL5274018 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL5271497 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL5290306 | — | IC50 | = | 115.0 | nM | 6.94 |
| CHEMBL5287408 | — | IC50 | = | 0.00018 | ug.mL-1 | - |
| CHEMBL2368118 | — | ED50 | = | 0.6 | ng/ml | - |
| CHEMBL5276170 | — | IC50 | = | 0.0006 | ug.mL-1 | - |
| CHEMBL5280902 | — | IC50 | = | 0.0006 | ug.mL-1 | - |
| CHEMBL5266350 | — | IC50 | = | 0.0004 | ug.mL-1 | - |
| CHEMBL5278649 | — | IC50 | = | 0.0011 | ug.mL-1 | - |
| CHEMBL5276892 | — | IC50 | = | 0.0022 | ug.mL-1 | - |
| CHEMBL5273750 | — | IC50 | = | 0.0002 | ug.mL-1 | - |
| CHEMBL5289800 | — | IC50 | = | 0.002 | ug.mL-1 | - |
| CHEMBL565513 | — | IC50 | = | 0.00406 | ug.mL-1 | - |
| CHEMBL5284941 | — | IC50 | = | 0.0032 | ug.mL-1 | - |
| CHEMBL361497 | ARTESUNATE | IC50 | = | 0.0012 | ug.mL-1 | - |
| CHEMBL404431 | OZ277 | IC50 | = | 0.001 | ug.mL-1 | - |
| CHEMBL227855 | — | IC50 | = | 0.00039 | ug.mL-1 | - |
| CHEMBL566534 | ARTEMETHER | IC50 | = | 0.00074 | ug.mL-1 | - |