Assay Detail
Functional
CHEMBL5247115
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Anticancer activity against human CCRF-CEM cells
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Geminal Diheteroatomic Motifs: Some Applications of Acetals, Ketals, and Their Sulfur and Nitrogen Homologues in Medicinal Chemistry and Drug Design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.38 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1619 | CLADRIBINE | 4.0 | 1 | 8.52 |
| CHEMBL1750 | CLOFARABINE | 4.0 | 1 | 7.22 |
| CHEMBL1096882 | FLUDARABINE PHOSPHATE | 4.0 | 1 | 6.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1619 | CLADRIBINE | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL1750 | CLOFARABINE | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL1096882 | FLUDARABINE PHOSPHATE | IC50 | = | 400.0 | nM | 6.40 |