Assay Detail
Functional
CHEMBL5249270
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Antiproliferative activity against human HL-60 cells assessed as inhibition of cell growth measured after 72 hrs by CCK8 assay
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HL-60 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Enantioselective semisynthesis of novel cephalotaxine esters with potent antineoplastic activities against leukemia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 6.38 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL46286 | OMACETAXINE MEPESUCCINATE | 4.0 | 1 | 7.89 |
| CHEMBL5290985 | — | — | 1 | 6.91 |
| CHEMBL5270562 | — | — | 1 | 6.89 |
| CHEMBL5270945 | — | — | 1 | 6.85 |
| CHEMBL5278139 | — | — | 1 | 6.84 |
| CHEMBL5274090 | — | — | 1 | 6.82 |
| CHEMBL5285936 | — | — | 1 | 6.82 |
| CHEMBL5278500 | — | — | 1 | 6.81 |
| CHEMBL5286145 | — | — | 1 | 6.81 |
| CHEMBL5270512 | — | — | 1 | 6.74 |
| CHEMBL5286384 | — | — | 1 | 6.70 |
| CHEMBL5279083 | — | — | 1 | 6.70 |
| CHEMBL5275058 | — | — | 1 | 6.63 |
| CHEMBL5286634 | — | — | 1 | 6.61 |
| CHEMBL5285826 | — | — | 1 | 6.58 |
| CHEMBL5275577 | — | — | 1 | 6.40 |
| CHEMBL5267122 | — | — | 1 | 6.27 |
| CHEMBL5271169 | — | — | 1 | 6.26 |
| CHEMBL5269685 | — | — | 1 | 6.25 |
| CHEMBL5266030 | — | — | 1 | 6.24 |
| CHEMBL5280250 | — | — | 1 | 6.22 |
| CHEMBL5276833 | — | — | 1 | 6.15 |
| CHEMBL5272045 | — | — | 1 | 6.14 |
| CHEMBL5285771 | — | — | 1 | 6.05 |
| CHEMBL5284070 | — | — | 1 | 6.04 |
| CHEMBL5416410 | DASATINIB | 4.0 | 1 | 4.83 |
| CHEMBL5268511 | — | — | 1 | 4.74 |
| CHEMBL941 | IMATINIB | 4.0 | 1 | 4.54 |
| CHEMBL276462 | CEPHALOTAXINE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL46286 | OMACETAXINE MEPESUCCINATE | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL5290985 | — | IC50 | = | 122.0 | nM | 6.91 |
| CHEMBL5270562 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL5270945 | — | IC50 | = | 142.0 | nM | 6.85 |
| CHEMBL5278139 | — | IC50 | = | 145.0 | nM | 6.84 |
| CHEMBL5274090 | — | IC50 | = | 153.0 | nM | 6.82 |
| CHEMBL5285936 | — | IC50 | = | 151.0 | nM | 6.82 |
| CHEMBL5278500 | — | IC50 | = | 155.0 | nM | 6.81 |
| CHEMBL5286145 | — | IC50 | = | 155.0 | nM | 6.81 |
| CHEMBL5270512 | — | IC50 | = | 184.0 | nM | 6.74 |
| CHEMBL5286384 | — | IC50 | = | 199.0 | nM | 6.70 |
| CHEMBL5279083 | — | IC50 | = | 202.0 | nM | 6.70 |
| CHEMBL5275058 | — | IC50 | = | 235.0 | nM | 6.63 |
| CHEMBL5286634 | — | IC50 | = | 246.0 | nM | 6.61 |
| CHEMBL5285826 | — | IC50 | = | 266.0 | nM | 6.58 |
| CHEMBL5275577 | — | IC50 | = | 396.0 | nM | 6.40 |
| CHEMBL5267122 | — | IC50 | = | 535.0 | nM | 6.27 |
| CHEMBL5271169 | — | IC50 | = | 548.0 | nM | 6.26 |
| CHEMBL5269685 | — | IC50 | = | 569.0 | nM | 6.25 |
| CHEMBL5266030 | — | IC50 | = | 576.0 | nM | 6.24 |
| CHEMBL5280250 | — | IC50 | = | 597.0 | nM | 6.22 |
| CHEMBL5276833 | — | IC50 | = | 701.0 | nM | 6.15 |
| CHEMBL5272045 | — | IC50 | = | 718.0 | nM | 6.14 |
| CHEMBL5285771 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL5284070 | — | IC50 | = | 907.0 | nM | 6.04 |
| CHEMBL5416410 | DASATINIB | IC50 | = | 14970.0 | nM | 4.83 |
| CHEMBL5268511 | — | IC50 | = | 18030.0 | nM | 4.74 |
| CHEMBL941 | IMATINIB | IC50 | = | 28540.0 | nM | 4.54 |
| CHEMBL276462 | CEPHALOTAXINE | IC50 | > | 30000.0 | nM | - |