Assay Detail
Binding
CHEMBL5251263
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Agonist activity at human TAS2R14 transfected in HEK293T cells assessed as IP1 accumulation measured after 150 mins by IP1 accumulation assay
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293T |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of 2-Aminopyrimidines as Potent Agonists for the Bitter Taste Receptor TAS2R14.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 32 | 6.30 | 7.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5279691 | — | — | 1 | 7.14 |
| CHEMBL5285591 | — | — | 1 | 7.01 |
| CHEMBL5273955 | — | — | 1 | 6.82 |
| CHEMBL5274304 | — | — | 1 | 6.80 |
| CHEMBL5277615 | — | — | 1 | 6.77 |
| CHEMBL5280542 | — | — | 1 | 6.75 |
| CHEMBL3623735 | — | — | 1 | 6.72 |
| CHEMBL5279381 | — | — | 1 | 6.72 |
| CHEMBL3088246 | — | — | 1 | 6.64 |
| CHEMBL5278834 | — | — | 1 | 6.52 |
| CHEMBL5277281 | — | — | 1 | 6.52 |
| CHEMBL5278171 | — | — | 1 | 6.48 |
| CHEMBL5274470 | — | — | 1 | 6.44 |
| CHEMBL5278477 | — | — | 1 | 6.42 |
| CHEMBL5275001 | — | — | 1 | 6.41 |
| CHEMBL5289590 | — | — | 1 | 6.38 |
| CHEMBL23588 | FLUFENAMIC ACID | 2.0 | 1 | 6.37 |
| CHEMBL5280688 | — | — | 1 | 6.27 |
| CHEMBL5286379 | — | — | 1 | 6.19 |
| CHEMBL5268924 | — | — | 1 | 6.19 |
| CHEMBL5279341 | — | — | 1 | 6.17 |
| CHEMBL5289980 | — | — | 1 | 6.12 |
| CHEMBL5276181 | — | — | 1 | 6.03 |
| CHEMBL22815 | — | — | 1 | 6.02 |
| CHEMBL5265924 | — | — | 1 | 5.96 |
| CHEMBL5268477 | — | — | 1 | 5.92 |
| CHEMBL5280454 | — | — | 1 | 5.85 |
| CHEMBL5274977 | — | — | 1 | 5.80 |
| CHEMBL5285283 | — | — | 1 | 5.75 |
| CHEMBL5288875 | — | — | 1 | 5.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5279691 | — | EC50 | = | 72.0 | nM | 7.14 |
| CHEMBL5285591 | — | EC50 | = | 98.0 | nM | 7.01 |
| CHEMBL5273955 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL5274304 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL5277615 | — | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL5280542 | — | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL3623735 | — | EC50 | = | 190.0 | nM | 6.72 |
| CHEMBL5279381 | — | EC50 | = | 190.0 | nM | 6.72 |
| CHEMBL3088246 | — | EC50 | = | 230.0 | nM | 6.64 |
| CHEMBL5278834 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL5277281 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL5278171 | — | EC50 | = | 330.0 | nM | 6.48 |
| CHEMBL5274470 | — | EC50 | = | 360.0 | nM | 6.44 |
| CHEMBL5278477 | — | EC50 | = | 380.0 | nM | 6.42 |
| CHEMBL5275001 | — | EC50 | = | 390.0 | nM | 6.41 |
| CHEMBL5289590 | — | EC50 | = | 420.0 | nM | 6.38 |
| CHEMBL23588 | FLUFENAMIC ACID | EC50 | = | 430.0 | nM | 6.37 |
| CHEMBL5280688 | — | EC50 | = | 540.0 | nM | 6.27 |
| CHEMBL5286379 | — | EC50 | = | 640.0 | nM | 6.19 |
| CHEMBL5268924 | — | EC50 | = | 640.0 | nM | 6.19 |
| CHEMBL5279341 | — | EC50 | = | 670.0 | nM | 6.17 |
| CHEMBL5289980 | — | EC50 | = | 750.0 | nM | 6.12 |
| CHEMBL5276181 | — | EC50 | = | 930.0 | nM | 6.03 |
| CHEMBL22815 | — | EC50 | = | 950.0 | nM | 6.02 |
| CHEMBL5265924 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL5268477 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL5280454 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL5274977 | — | EC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL5285283 | — | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL5288875 | — | EC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL5265867 | — | EC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL5279932 | — | EC50 | = | 6800.0 | nM | 5.17 |