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Compound Detail

CHEMBL5273955

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C#Cc1cc(Nc2ccccc2C(=O)O)cc(C(F)(F)F)c1

Basic Information

ChEMBL ID CHEMBL5273955
Phase Preclinical
Structure Type MOL
InChI Key ADYZEYUMYXAEPW-UHFFFAOYSA-N
3
Targets
3
Activities
2
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

305.2
MW (Da)
4.13
ALogP
2
HBA
2
HBD
49.3
PSA (Ų)
0.84
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C16H10F3NO2
MW 305.25
Aromatic Rings 2
Heavy Atoms 22
NP-Likeness -1.35

Activity Summary

Ki 2 meas. best 4.8
EC50 1 meas. best 6.82

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Taste receptor type 2 member 14
CHEMBL3309105
EC50 6.82 6.82 150.0 1
Alpha-2B adrenergic receptor
CHEMBL1942
Ki 4.8 4.8 16000.0 1
Alpha-2C adrenergic receptor
CHEMBL1916
Ki 4.77 4.77 17000.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
36847646 10.1021/acs.jmedchem.2c01997 Taste receptor type 2 member 14 2
36847646 10.1021/acs.jmedchem.2c01997 Alpha-2B adrenergic receptor 1
36847646 10.1021/acs.jmedchem.2c01997 Alpha-2C adrenergic receptor 1

Data from ChEMBL 36 via Core Engine