Assay Detail
Toxicity
CHEMBL5251390
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Cytotoxicity against mouse HT-22 cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay
56
Total Activities
56
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Mus musculus |
| Cell Type | HT-22 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Comparative Efficacy and Selectivity of Pharmacological Inhibitors of DYRK and CLK Protein Kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 56 | 4.86 | 6.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL393525 | — | — | 1 | 6.80 |
| CHEMBL4784318 | CIRTUVIVINT | 1.0 | 1 | 6.75 |
| CHEMBL608533 | MIDOSTAURIN | 4.0 | 1 | 6.00 |
| CHEMBL5280761 | — | — | 1 | 6.00 |
| CHEMBL4297639 | LORECIVIVINT | 3.0 | 1 | 5.68 |
| CHEMBL184574 | DEMETHYLBELLIDIFOLIN | — | 1 | 5.60 |
| CHEMBL4754195 | — | — | 1 | 5.58 |
| CHEMBL5289681 | — | — | 1 | 5.31 |
| CHEMBL4873449 | — | — | 1 | 5.26 |
| CHEMBL790 | CHLORHEXIDINE | 4.0 | 1 | 5.25 |
| CHEMBL4441878 | — | — | 1 | 5.24 |
| CHEMBL5285332 | — | — | 1 | 5.23 |
| CHEMBL5091238 | — | — | 1 | 5.20 |
| CHEMBL5070553 | — | — | 1 | 5.11 |
| CHEMBL5288391 | — | — | 1 | 5.10 |
| CHEMBL4798421 | — | — | 1 | 5.09 |
| CHEMBL4292553 | — | — | 1 | 5.05 |
| CHEMBL5283849 | — | — | 1 | 4.97 |
| CHEMBL3301610 | ABEMACICLIB | 4.0 | 1 | 4.91 |
| CHEMBL5095897 | — | — | 1 | 4.84 |
| CHEMBL5286716 | — | — | 1 | 4.83 |
| CHEMBL4647659 | — | — | 1 | 4.79 |
| CHEMBL5273528 | — | — | 1 | 4.70 |
| CHEMBL5279705 | — | — | 1 | 4.68 |
| CHEMBL3894571 | — | — | 1 | 4.67 |
| CHEMBL1230165 | SILMITASERTIB | 2.0 | 1 | 4.67 |
| CHEMBL297453 | EPIGALOCATECHIN GALLATE | 3.0 | 1 | 4.62 |
| CHEMBL5081787 | — | — | 1 | 4.56 |
| CHEMBL3421968 | — | — | 1 | 4.56 |
| CHEMBL4637319 | — | — | 1 | 4.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL393525 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4784318 | CIRTUVIVINT | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL5280761 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4297639 | LORECIVIVINT | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL184574 | DEMETHYLBELLIDIFOLIN | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL4754195 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL5289681 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL4873449 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL790 | CHLORHEXIDINE | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL4441878 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL5285332 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL5091238 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL5070553 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL5288391 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL4798421 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL4292553 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL5283849 | — | IC50 | = | 10800.0 | nM | 4.97 |
| CHEMBL3301610 | ABEMACICLIB | IC50 | = | 12200.0 | nM | 4.91 |
| CHEMBL5095897 | — | IC50 | = | 14500.0 | nM | 4.84 |
| CHEMBL5286716 | — | IC50 | = | 14700.0 | nM | 4.83 |
| CHEMBL4647659 | — | IC50 | = | 16300.0 | nM | 4.79 |
| CHEMBL5273528 | — | IC50 | = | 19900.0 | nM | 4.70 |
| CHEMBL5279705 | — | IC50 | = | 20900.0 | nM | 4.68 |
| CHEMBL1230165 | SILMITASERTIB | IC50 | = | 21300.0 | nM | 4.67 |
| CHEMBL3894571 | — | IC50 | = | 21600.0 | nM | 4.67 |
| CHEMBL297453 | EPIGALOCATECHIN GALLATE | IC50 | = | 23800.0 | nM | 4.62 |
| CHEMBL5081787 | — | IC50 | = | 27800.0 | nM | 4.56 |
| CHEMBL3421968 | — | IC50 | = | 27800.0 | nM | 4.56 |
| CHEMBL4637319 | — | IC50 | = | 30100.0 | nM | 4.52 |
| CHEMBL1094636 | NIRAPARIB | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL3298236 | — | IC50 | = | 42500.0 | nM | 4.37 |
| CHEMBL1614713 | CC-401 | IC50 | = | 51700.0 | nM | 4.29 |
| CHEMBL5093741 | — | IC50 | = | 51300.0 | nM | 4.29 |
| CHEMBL140 | CURCUMIN | IC50 | = | 52400.0 | nM | 4.28 |
| CHEMBL1997924 | — | IC50 | = | 54000.0 | nM | 4.27 |
| CHEMBL269538 | HARMINE | IC50 | = | 56500.0 | nM | 4.25 |
| CHEMBL1173055 | RUCAPARIB | IC50 | = | 57000.0 | nM | 4.24 |
| CHEMBL4848254 | — | IC50 | = | 58600.0 | nM | 4.23 |
| CHEMBL5272336 | — | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL4288096 | — | IC50 | = | 64800.0 | nM | 4.19 |
| CHEMBL418971 | BISPHENOL A | IC50 | = | 97000.0 | nM | 4.01 |
| CHEMBL4283240 | — | IC50 | = | 97000.0 | nM | 4.01 |
| CHEMBL4783398 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL5288595 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL1232500 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL485053 | LEUCETTAMINE B | IC50 | > | 100000.0 | nM | - |
| CHEMBL3185434 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5284529 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1236620 | — | IC50 | > | 100000.0 | nM | - |