Assay Detail
Binding
CHEMBL5251992
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to sigma 1 receptor (unknown origin) assessed as inhibition constant
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sigma non-opioid intracellular receptor 1 (CHEMBL287) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Development of Fluorescent 4-[4-(3<i>H</i>-Spiro[isobenzofuran-1,4'-piperidin]-1'-yl)butyl]indolyl Derivatives as High-Affinity Probes to Enable the Study of σ Receptors via Fluorescence-Based Techniques.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 9.05 | 10.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3763396 | — | — | 1 | 10.52 |
| CHEMBL53325 | — | — | 1 | 9.42 |
| CHEMBL5272035 | — | — | 1 | 8.27 |
| CHEMBL61479 | SIRAMESINE | 2.0 | 1 | 7.98 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3763396 | — | Ki | = | 0.03 | nM | 10.52 |
| CHEMBL53325 | — | Ki | = | 0.38 | nM | 9.42 |
| CHEMBL5272035 | — | Ki | = | 5.37 | nM | 8.27 |
| CHEMBL61479 | SIRAMESINE | Ki | = | 10.5 | nM | 7.98 |