Assay Detail
Binding
CHEMBL5254843
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of C-terminal his tagged human PD-1/human Fc tagged PDL-1 interaction expressed in HEK293 cells incubated for 2 hrs AlphaScreen assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Programmed cell death protein 1/Programmed cell death 1 ligand 1 (CHEMBL4523993) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Thorectidiol A Isolated from the Marine Sponge <i>Dactylospongia elegans</i> Disrupts Interactions of the SARS-CoV-2 Spike Receptor Binding Domain with the Host ACE2 Receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.59 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4071326 | — | — | 1 | 8.52 |
| CHEMBL5267016 | — | — | 1 | 5.22 |
| CHEMBL5283695 | — | — | 1 | 4.43 |
| CHEMBL5276399 | — | — | 1 | 4.18 |
| CHEMBL5282197 | — | — | 1 | - |
| CHEMBL384120 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4071326 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL5267016 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL5283695 | — | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL5276399 | — | IC50 | = | 66000.0 | nM | 4.18 |
| CHEMBL5282197 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL384120 | — | IC50 | - | — | - |