Assay Detail
Functional
CHEMBL5255118
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Reversal of HIV-1 latency infected in GFP-fused human J-Lat 10.6 cells assessed as inhibition of 160 nM PMA-induced HIV production incubated for 24 hrs by flow cytometry analysis
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | J-Lat 10.6 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Using a Bioactive <i>Eremophila</i>-Derived Serrulatane Scaffold to Generate a Unique Carbamate Library for Anti-infective Evaluations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 4.01 | 4.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5275076 | — | — | 1 | 4.01 |
| CHEMBL5271594 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5275076 | — | EC50 | = | 96700.0 | nM | 4.01 |
| CHEMBL5271594 | — | EC50 | = | 146200.0 | nM | - |