Assay Detail

CHEMBL5258076

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Functional

Antitrypanosomal activity against Trypanosoma cruzi amastigote

ChEMBL ↗

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Target

Trypanosoma cruzi (CHEMBL368) ↗

Open DB target context

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Trypanosoma cruzi (CHEMBL368) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Trypanosoma cruzi

CHEMBL368

Anchored from Assay target.

Protein identity Trypanosoma cruzi

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Trypanosoma cruzi
Confidence	1 — Organism
Curated By	Autocuration

Target

Trypanosoma cruzi (CHEMBL368) ↗

Type	ORGANISM
Organism	Trypanosoma cruzi

Publication

Active Natural Product Scaffolds against Trypanosomatid Parasites: A Review.

Cockram PE, Smith TK.
J Nat Prod (2018) 81 : 2138 -2154
PubMed 30234295 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
EC50	2	6.30	6.89

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL524291	STERIGMATOCYSTIN	—	1	6.89
CHEMBL115585	NEOCRYPTOLEPINE	—	1	5.70

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL524291	STERIGMATOCYSTIN	EC50	=	130.0	nM	6.89
CHEMBL115585	NEOCRYPTOLEPINE	EC50	=	2000.0	nM	5.70