Assay Detail
Functional
CHEMBL5260168
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Antiproliferative activity against human T47D cells incubated for 72 hrs by Celltiter-glo assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | T47D |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of pyrido[4,3-d]pyrimidinone derivatives as novel Wee1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 5.12 | 5.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5282089 | — | — | 1 | 5.57 |
| CHEMBL5270868 | — | — | 1 | 5.49 |
| CHEMBL5283522 | — | — | 1 | 5.38 |
| CHEMBL5285904 | — | — | 1 | 5.37 |
| CHEMBL5283512 | — | — | 1 | 5.33 |
| CHEMBL5268364 | — | — | 1 | 5.33 |
| CHEMBL5274135 | — | — | 1 | 5.30 |
| CHEMBL5280543 | — | — | 1 | 5.19 |
| CHEMBL5287491 | — | — | 1 | 5.02 |
| CHEMBL5284507 | — | — | 1 | 4.98 |
| CHEMBL1976040 | ADAVOSERTIB | 2.0 | 1 | 4.89 |
| CHEMBL5291088 | — | — | 1 | 4.86 |
| CHEMBL5288846 | — | — | 1 | 4.86 |
| CHEMBL5269748 | — | — | 1 | 4.84 |
| CHEMBL5266280 | — | — | 1 | 4.72 |
| CHEMBL5269331 | — | — | 1 | 4.72 |
| CHEMBL5289322 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5282089 | — | IC50 | = | 2670.0 | nM | 5.57 |
| CHEMBL5270868 | — | IC50 | = | 3230.0 | nM | 5.49 |
| CHEMBL5283522 | — | IC50 | = | 4130.0 | nM | 5.38 |
| CHEMBL5285904 | — | IC50 | = | 4230.0 | nM | 5.37 |
| CHEMBL5283512 | — | IC50 | = | 4680.0 | nM | 5.33 |
| CHEMBL5268364 | — | IC50 | = | 4640.0 | nM | 5.33 |
| CHEMBL5274135 | — | IC50 | = | 5030.0 | nM | 5.30 |
| CHEMBL5280543 | — | IC50 | = | 6390.0 | nM | 5.19 |
| CHEMBL5287491 | — | IC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL5284507 | — | IC50 | = | 10450.0 | nM | 4.98 |
| CHEMBL1976040 | ADAVOSERTIB | IC50 | = | 12780.0 | nM | 4.89 |
| CHEMBL5291088 | — | IC50 | = | 13950.0 | nM | 4.86 |
| CHEMBL5288846 | — | IC50 | = | 13700.0 | nM | 4.86 |
| CHEMBL5269748 | — | IC50 | = | 14410.0 | nM | 4.84 |
| CHEMBL5266280 | — | IC50 | = | 18830.0 | nM | 4.72 |
| CHEMBL5269331 | — | IC50 | = | 19200.0 | nM | 4.72 |
| CHEMBL5289322 | — | IC50 | > | 20000.0 | nM | - |