Assay Detail
Functional
CHEMBL5260642
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Antiviral activity against HCoV-229E infected in human HEL 299 cells assessed as inhibition of virus-induced cytopathogenic effect incubated for 3 to 7 days by MTS assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human coronavirus 229E |
| Cell Type | HEL 299 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Biological evaluation of novel amidino substituted coumarin-benzazole hybrids as promising therapeutic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 5.26 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4065616 | REMDESIVIR | 4.0 | 1 | 7.22 |
| CHEMBL5276739 | — | — | 1 | 4.48 |
| CHEMBL1643 | RIBAVIRIN | 4.0 | 1 | 4.08 |
| CHEMBL5274445 | — | — | 1 | - |
| CHEMBL5286680 | — | — | 1 | - |
| CHEMBL5287724 | — | — | 1 | - |
| CHEMBL5271525 | — | — | 1 | - |
| CHEMBL5266539 | — | — | 1 | - |
| CHEMBL5274153 | — | — | 1 | - |
| CHEMBL5284601 | — | — | 1 | - |
| CHEMBL5273678 | — | — | 1 | - |
| CHEMBL5289851 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4065616 | REMDESIVIR | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL5276739 | — | EC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL1643 | RIBAVIRIN | EC50 | = | 82600.0 | nM | 4.08 |
| CHEMBL5274445 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL5286680 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL5287724 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL5271525 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL5266539 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL5274153 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL5284601 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL5273678 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL5289851 | — | EC50 | > | 100000.0 | nM | - |