Assay Detail
Functional
CHEMBL5260651
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against Zika virus Mr776 infected in human Huh-7 cells assessed as inhibition of virus-induced cytopathogenic effect incubated for 3 to 7 days by MTS assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Zika virus |
| Cell Type | Huh-7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Biological evaluation of novel amidino substituted coumarin-benzazole hybrids as promising therapeutic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 5.10 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4065616 | REMDESIVIR | 4.0 | 1 | 6.16 |
| CHEMBL5271525 | — | — | 1 | 5.03 |
| CHEMBL5273678 | — | — | 1 | 4.11 |
| CHEMBL5274445 | — | — | 1 | - |
| CHEMBL5286680 | — | — | 1 | - |
| CHEMBL5287724 | — | — | 1 | - |
| CHEMBL5266539 | — | — | 1 | - |
| CHEMBL5274153 | — | — | 1 | - |
| CHEMBL5284601 | — | — | 1 | - |
| CHEMBL5289851 | — | — | 1 | - |
| CHEMBL5276739 | — | — | 1 | - |
| CHEMBL1643 | RIBAVIRIN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4065616 | REMDESIVIR | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL5271525 | — | EC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL5273678 | — | EC50 | = | 77700.0 | nM | 4.11 |
| CHEMBL5274445 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL5286680 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL5287724 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL5266539 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL5274153 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL5284601 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL5289851 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL5276739 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1643 | RIBAVIRIN | EC50 | > | 250000.0 | nM | - |