Assay Detail
Binding
CHEMBL5260674
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human full length PI5P4Kalpha expressed in Escherichia coli BL21(DE3) pre-incubated for 15 mins followed by ATP addition measured after 1 hr by TR-FRET assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (CHEMBL1795194) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of ARUK2002821 as an isoform-selective PI5P4Kα inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 4.75 | 4.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2104863 | IMANIXIL | 2.0 | 1 | 4.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2104863 | IMANIXIL | IC50 | = | 18000.0 | nM | 4.75 |