Compound Detail
CHEMBL2104863
IMANIXIL 🧪 Phase II
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🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL2104863 |
| Name | IMANIXIL |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | FUSNOPLQVRUIIM-UHFFFAOYSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
2
Known Names
Molecular Properties
394.4
MW (Da)
2.64
ALogP
5
HBA
3
HBD
113.2
PSA (Ų)
0.74
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Achiral |
Activity Summary
IC50 3 meas. best 5.68
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Phosphatidylinositol 5-phosphate 4-kinase type-2 beta CHEMBL5667 | IC50 | 5.68 | 5.55 | 2100.0 | 2 |
| Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha CHEMBL1795194 | IC50 | 4.75 | 4.75 | 18000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Phosphatidylinositol 5-phosphate 4-kinase type-2 beta | IC50 | = | 2100.0 | nM | 5.68 | Inhibition of human full length PI5P4Kbeta expressed in Escherichia coli BL21(DE... | 37252102 |
| Phosphatidylinositol 5-phosphate 4-kinase type-2 beta | IC50 | = | 3800.0 | nM | 5.42 | Inhibition of PI5P4Kbeta (unknown origin) incubated for 15 mins in presence of A... | 32184968 |
| Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha | IC50 | = | 18000.0 | nM | 4.75 | Inhibition of human full length PI5P4Kalpha expressed in Escherichia coli BL21(D... | 37252102 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 32184968 | 10.1021/acsmedchemlett.9b00402 | Phosphatidylinositol 5-phosphate 4-kinase type-2 beta | 1 |
| 37252102 | 10.1039/d3md00039g | Phosphatidylinositol 5-phosphate 4-kinase type-2 beta | 1 |
| 37252102 | 10.1039/d3md00039g | Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha | 1 |
Data from ChEMBL 36 via Core Engine