Assay Detail
Binding
CHEMBL5262869
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of SYK in human Ramos cells assessed as reduction in anti IgM-induced phosphorylation of BLNK by flow cytometry assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Ramos |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
An overview on the recent developments of 1,2,4-triazine derivatives as anticancer compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.85 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3416026 | — | — | 1 | 7.85 |
| CHEMBL3965225 | — | — | 1 | 7.85 |
| CHEMBL3932871 | — | — | 1 | 7.85 |
| CHEMBL3416027 | — | — | 1 | 7.85 |
| CHEMBL3962214 | — | — | 1 | 7.85 |
| CHEMBL3967315 | — | — | 1 | 7.85 |
| CHEMBL3893313 | — | — | 1 | 7.85 |
| CHEMBL3930413 | — | — | 1 | 7.85 |
| CHEMBL3962915 | — | — | 1 | 7.85 |
| CHEMBL3899231 | — | — | 1 | 7.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3416026 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL3965225 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL3932871 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL3416027 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL3962214 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL3967315 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL3893313 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL3930413 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL3962915 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL3899231 | — | IC50 | = | 14.0 | nM | 7.85 |