Compound Detail
CHEMBL3962915
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Basic Information
| ChEMBL ID | CHEMBL3962915 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | XDTVNHHINGTFKX-GXFFZTMASA-N |
1
Targets
3
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
367.4
MW (Da)
1.27
ALogP
8
HBA
5
HBD
160.5
PSA (Ų)
0.45
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 9.1
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Tyrosine-protein kinase SYK CHEMBL2599 | IC50 | 9.1 | 8.1567 | 0.8 | 3 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Tyrosine-protein kinase SYK | IC50 | = | 0.8 | nM | 9.1 | Inhibition of human SYK using 5-Fluo-Ahx-GAPDYENLQELNKK-Amid as substrate in pre... | 28851503 |
| Tyrosine-protein kinase SYK | IC50 | = | 14.0 | nM | 7.85 | Inhibition of SYK in human Ramos cells assessed as reduction in anti IgM-induced... | 28851503 |
| Tyrosine-protein kinase SYK | IC50 | = | 30.0 | nM | 7.52 | Chip Based Microfluidic Mobility Shift Assay: All assays were performed in 384 w... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 28851503 | 10.1016/j.ejmech.2017.08.009 | Tyrosine-protein kinase SYK | 2 |
Data from ChEMBL 36 via Core Engine