Assay Detail

CHEMBL5263084

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Functional

Antiprotozoal activity against Trypanosoma cruzi infected in Rhesus monkey LLC-MK2 cells

ChEMBL ↗

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Target

Trypanosoma cruzi (CHEMBL368) ↗

Open DB target context

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Trypanosoma cruzi (CHEMBL368) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Trypanosoma cruzi

CHEMBL368

Anchored from Assay target.

Protein identity Trypanosoma cruzi

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Trypanosoma cruzi
Cell Type	LLC-MK2
Confidence	1 — Organism
Curated By	Autocuration

Target

Trypanosoma cruzi (CHEMBL368) ↗

Type	ORGANISM
Organism	Trypanosoma cruzi

Publication

Polyamine-based analogs and conjugates as antikinetoplastid agents.

Jagu E, Pomel S, Pethe S, Loiseau PM, Labruère R.
Eur J Med Chem (2017) 139 : 982 -1015
PubMed 28886510 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	6.30	6.30

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL561057	SQ109	2.0	1	6.30

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL561057	SQ109	IC50	=	500.0	nM	6.30