Assay Detail
Functional
CHEMBL5263128
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Antiprotozoal activity against Trypanosoma brucei
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Polyamine-based analogs and conjugates as antikinetoplastid agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.97 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5272888 | — | — | 1 | 9.40 |
| CHEMBL5288670 | — | — | 1 | 9.40 |
| CHEMBL587208 | — | — | 1 | 9.00 |
| CHEMBL5274009 | — | — | 1 | 8.40 |
| CHEMBL5287624 | — | — | 1 | 8.40 |
| CHEMBL305575 | — | — | 1 | 6.72 |
| CHEMBL5287733 | — | — | 1 | 6.44 |
| CHEMBL5289412 | — | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5272888 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL5288670 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL587208 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL5274009 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL5287624 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL305575 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL5287733 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL5289412 | — | IC50 | = | 1000.0 | nM | 6.00 |