Assay Detail

CHEMBL5265127

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Functional

Antiinflammatory activity in carrageenan induced rat paw edema model assessed inhibition of TNF-alpha level

ChEMBL ↗

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Target

Rattus norvegicus (CHEMBL376) ↗

Open DB target context

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Rattus norvegicus (CHEMBL376) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Rattus norvegicus

CHEMBL376

Anchored from Assay target.

Protein identity Rattus norvegicus

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Rattus norvegicus
Confidence	1 — Organism
Curated By	Autocuration

Target

Rattus norvegicus (CHEMBL376) ↗

Type	ORGANISM
Organism	Rattus norvegicus

Publication

Recent advancements in the development of bioactive pyrazoline derivatives.

Nehra B, Rulhania S, Jaswal S, Kumar B, Singh G, Monga V.
Eur J Med Chem (2020) 205 : 112666 -112666
PubMed 32795767 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	8.02	8.77

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL5289271	—	—	1	8.77
CHEMBL140	CURCUMIN	3.0	1	7.27

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL5289271	—	IC50	=	1.7	nM	8.77
CHEMBL140	CURCUMIN	IC50	=	53.4	nM	7.27