Assay Detail
Binding
CHEMBL5265489
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Inhibition of ACK1 (unknown origin)
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Small Molecules Targeting Activated Cdc42-Associated Kinase 1 (ACK1/TNK2) for the Treatment of Cancers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.39 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5416410 | DASATINIB | 4.0 | 1 | 9.00 |
| CHEMBL288441 | BOSUTINIB | 4.0 | 1 | 8.57 |
| CHEMBL1229517 | VEMURAFENIB | 4.0 | 1 | 7.72 |
| CHEMBL2403108 | CERITINIB | 4.0 | 1 | 7.47 |
| CHEMBL3353410 | OSIMERTINIB | 4.0 | 1 | 7.15 |
| CHEMBL53753 | — | — | 1 | 6.70 |
| CHEMBL535 | SUNITINIB | 4.0 | 1 | 5.11 |
| CHEMBL939 | GEFITINIB | 4.0 | 1 | - |
| CHEMBL428690 | ALVOCIDIB | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5416410 | DASATINIB | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL288441 | BOSUTINIB | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL1229517 | VEMURAFENIB | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL2403108 | CERITINIB | IC50 | = | 33.6 | nM | 7.47 |
| CHEMBL3353410 | OSIMERTINIB | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL53753 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL535 | SUNITINIB | IC50 | = | 7830.0 | nM | 5.11 |
| CHEMBL939 | GEFITINIB | IC50 | < | 20000.0 | nM | - |
| CHEMBL428690 | ALVOCIDIB | IC50 | < | 20000.0 | nM | - |