Assay Detail
Binding
CHEMBL5265688
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at Gal4-fused mouse PPAR-delta ligand binding domain expressed in CHO-K1 cells assessed as receptor transactivation incubated for 24 to 48 hrs by luciferase reporter gene assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Peroxisome proliferator-activated receptor delta (CHEMBL2458) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Discovery and structure-activity relationship study of 2-piperazinyl-benzothiazole derivatives as potent and selective PPARδ agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 24 | 7.59 | 8.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5267473 | — | — | 1 | 8.24 |
| CHEMBL5272996 | — | — | 1 | 8.21 |
| CHEMBL5283926 | — | — | 1 | 8.21 |
| CHEMBL5289740 | — | — | 1 | 8.16 |
| CHEMBL5290870 | — | — | 1 | 8.16 |
| CHEMBL5277165 | — | — | 1 | 8.12 |
| CHEMBL5278892 | — | — | 1 | 7.92 |
| CHEMBL5290260 | — | — | 1 | 7.92 |
| CHEMBL5289017 | — | — | 1 | 7.62 |
| CHEMBL5271479 | — | — | 1 | 7.60 |
| CHEMBL5268424 | — | — | 1 | 7.58 |
| CHEMBL5285352 | — | — | 1 | 7.57 |
| CHEMBL5279586 | — | — | 1 | 7.55 |
| CHEMBL5268646 | — | — | 1 | 7.47 |
| CHEMBL5273427 | — | — | 1 | 7.41 |
| CHEMBL5288454 | — | — | 1 | 7.34 |
| CHEMBL5278648 | — | — | 1 | 7.33 |
| CHEMBL5281528 | — | — | 1 | 7.33 |
| CHEMBL5271300 | — | — | 1 | 7.21 |
| CHEMBL5180073 | — | — | 1 | 7.15 |
| CHEMBL38943 | GW501516 | 2.0 | 1 | 7.12 |
| CHEMBL5279568 | — | — | 1 | 7.10 |
| CHEMBL5272924 | — | — | 1 | 6.96 |
| CHEMBL5267326 | — | — | 1 | 6.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5267473 | — | EC50 | = | 5.8 | nM | 8.24 |
| CHEMBL5272996 | — | EC50 | = | 6.2 | nM | 8.21 |
| CHEMBL5283926 | — | EC50 | = | 6.1 | nM | 8.21 |
| CHEMBL5289740 | — | EC50 | = | 6.9 | nM | 8.16 |
| CHEMBL5290870 | — | EC50 | = | 6.9 | nM | 8.16 |
| CHEMBL5277165 | — | EC50 | = | 7.5 | nM | 8.12 |
| CHEMBL5278892 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL5290260 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL5289017 | — | EC50 | = | 24.0 | nM | 7.62 |
| CHEMBL5271479 | — | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL5268424 | — | EC50 | = | 26.0 | nM | 7.58 |
| CHEMBL5285352 | — | EC50 | = | 27.0 | nM | 7.57 |
| CHEMBL5279586 | — | EC50 | = | 28.0 | nM | 7.55 |
| CHEMBL5268646 | — | EC50 | = | 34.0 | nM | 7.47 |
| CHEMBL5273427 | — | EC50 | = | 39.0 | nM | 7.41 |
| CHEMBL5288454 | — | EC50 | = | 46.0 | nM | 7.34 |
| CHEMBL5278648 | — | EC50 | = | 47.0 | nM | 7.33 |
| CHEMBL5281528 | — | EC50 | = | 47.0 | nM | 7.33 |
| CHEMBL5271300 | — | EC50 | = | 61.0 | nM | 7.21 |
| CHEMBL5180073 | — | EC50 | = | 71.0 | nM | 7.15 |
| CHEMBL38943 | GW501516 | EC50 | = | 76.0 | nM | 7.12 |
| CHEMBL5279568 | — | EC50 | = | 79.0 | nM | 7.10 |
| CHEMBL5272924 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL5267326 | — | EC50 | = | 110.0 | nM | 6.96 |