Compound Detail
CHEMBL5267326
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Basic Information
| ChEMBL ID | CHEMBL5267326 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | OJPGGLJMCHLEIK-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
446.0
MW (Da)
4.09
ALogP
6
HBA
1
HBD
65.9
PSA (Ų)
0.59
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 7.48
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Peroxisome proliferator-activated receptor delta CHEMBL3979 | EC50 | 7.48 | 7.48 | 33.0 | 1 |
| Peroxisome proliferator-activated receptor delta CHEMBL2458 | EC50 | 6.96 | 6.96 | 110.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Peroxisome proliferator-activated receptor delta | EC50 | = | 33.0 | nM | 7.48 | Agonist activity at Gal4-fused human PPAR-delta ligand binding domain expressed ... | 36840990 |
| Peroxisome proliferator-activated receptor delta | EC50 | = | 110.0 | nM | 6.96 | Agonist activity at Gal4-fused mouse PPAR-delta ligand binding domain expressed ... | 36840990 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 36840990 | 10.1016/j.bmc.2023.117215 | Peroxisome proliferator-activated receptor delta | 4 |
Data from ChEMBL 36 via Core Engine