Assay Detail
Functional
CHEMBL5317289
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Antiproliferative activity against human A2780 cells incubated for 72 hrs in carbon-dioxide atmosphere measured by cell counting kit-8 method
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A2780 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Highly Potent Nicotinamide Phosphoribosyltransferase Degraders for Efficient Treatment of Ovarian Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 7.01 | 9.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL566757 | DAPORINAD | 2.0 | 1 | 9.55 |
| CHEMBL5414758 | — | — | 1 | 8.82 |
| CHEMBL5394965 | — | — | 1 | 8.23 |
| CHEMBL5402956 | — | — | 1 | 8.00 |
| CHEMBL5401852 | — | — | 1 | 7.52 |
| CHEMBL5396943 | — | — | 1 | 7.52 |
| CHEMBL5425579 | — | — | 1 | 7.25 |
| CHEMBL5437058 | — | — | 1 | 7.02 |
| CHEMBL1586371 | — | — | 1 | 6.89 |
| CHEMBL5405720 | — | — | 1 | 6.88 |
| CHEMBL5418877 | — | — | 1 | 6.76 |
| CHEMBL5406636 | — | — | 1 | 6.40 |
| CHEMBL5408654 | — | — | 1 | 6.36 |
| CHEMBL5412973 | — | — | 1 | 6.32 |
| CHEMBL5403078 | — | — | 1 | 6.31 |
| CHEMBL5414864 | — | — | 1 | 6.15 |
| CHEMBL5431029 | — | — | 1 | 6.13 |
| CHEMBL5405525 | — | — | 1 | 5.91 |
| CHEMBL5423357 | — | — | 1 | 5.26 |
| CHEMBL4565531 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL566757 | DAPORINAD | IC50 | = | 0.28 | nM | 9.55 |
| CHEMBL5414758 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL5394965 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL5402956 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5401852 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL5396943 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL5425579 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL5437058 | — | IC50 | = | 96.0 | nM | 7.02 |
| CHEMBL1586371 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL5405720 | — | IC50 | = | 133.0 | nM | 6.88 |
| CHEMBL5418877 | — | IC50 | = | 173.0 | nM | 6.76 |
| CHEMBL5406636 | — | IC50 | = | 401.0 | nM | 6.40 |
| CHEMBL5408654 | — | IC50 | = | 433.0 | nM | 6.36 |
| CHEMBL5412973 | — | IC50 | = | 477.0 | nM | 6.32 |
| CHEMBL5403078 | — | IC50 | = | 487.0 | nM | 6.31 |
| CHEMBL5414864 | — | IC50 | = | 707.0 | nM | 6.15 |
| CHEMBL5431029 | — | IC50 | = | 737.0 | nM | 6.13 |
| CHEMBL5405525 | — | IC50 | = | 1227.0 | nM | 5.91 |
| CHEMBL5423357 | — | IC50 | = | 5512.0 | nM | 5.26 |
| CHEMBL4565531 | — | IC50 | > | 100000.0 | nM | - |