Assay Detail
Binding
CHEMBL5318152
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of SERT receptor (unknown origin)
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent serotonin transporter (CHEMBL228) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Deciphering Nonbioavailable Substructures Improves the Bioavailability of Antidepressants by Serotonin Transporter.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 9.16 | 9.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5420565 | — | — | 1 | 9.49 |
| CHEMBL5431204 | — | — | 1 | 9.46 |
| CHEMBL439849 | VILAZODONE | 4.0 | 1 | 9.32 |
| CHEMBL5438420 | — | — | 1 | 9.24 |
| CHEMBL2104993 | VORTIOXETINE | 4.0 | 1 | 8.27 |
| CHEMBL5413412 | — | — | 1 | - |
| CHEMBL5394701 | — | — | 1 | - |
| CHEMBL5423624 | — | — | 1 | - |
| CHEMBL5407190 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5420565 | — | IC50 | = | 0.32 | nM | 9.49 |
| CHEMBL5431204 | — | IC50 | = | 0.35 | nM | 9.46 |
| CHEMBL439849 | VILAZODONE | IC50 | = | 0.48 | nM | 9.32 |
| CHEMBL5438420 | — | IC50 | = | 0.58 | nM | 9.24 |
| CHEMBL2104993 | VORTIOXETINE | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL5413412 | — | IC50 | < | 2.0 | nM | - |
| CHEMBL5394701 | — | IC50 | < | 2.0 | nM | - |
| CHEMBL5423624 | — | IC50 | < | 2.0 | nM | - |
| CHEMBL5407190 | — | IC50 | < | 2.0 | nM | - |