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Assay Detail

CHEMBL5318947

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of JNK1 (unknown origin) using ULight-4E-BP1 peptide as substrate incubated for 90 mins in presence of ATP by Lance ultra assay
68
Total Activities
68
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Mitogen-activated protein kinase 8 (CHEMBL2276)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Discovery of Novel Indazole Chemotypes as Isoform-Selective JNK3 Inhibitors for the Treatment of Parkinson's Disease.
Shuai W, Bu F, Zhu Y, Wu Y, Xiao H, Pan X, Zhang J, Sun Q, Wang G, Ouyang L.
J Med Chem (2023) 66 : 1273 -1300
PubMed 36649216 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 68 5.13 7.37

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL252761 1 7.37
CHEMBL5411091 1 5.14
CHEMBL5437584 1 5.13
CHEMBL5428091 1 5.12
CHEMBL5402580 1 5.12
CHEMBL5411375 1 5.12
CHEMBL5403784 1 5.12
CHEMBL5405579 1 5.12
CHEMBL5439708 1 5.11
CHEMBL5435391 1 5.11
CHEMBL5403866 1 5.11
CHEMBL5408361 1 5.11
CHEMBL5408918 1 5.11
CHEMBL5437979 1 5.11
CHEMBL5423687 1 5.11
CHEMBL5437251 1 5.11
CHEMBL5432287 1 5.11
CHEMBL5436065 1 5.10
CHEMBL5409834 1 5.10
CHEMBL5439622 1 5.09
CHEMBL5433156 1 5.09
CHEMBL5433711 1 5.08
CHEMBL5441124 1 5.08
CHEMBL5437898 1 5.07
CHEMBL5398897 1 5.07
CHEMBL5397012 1 5.07
CHEMBL5428502 1 5.07
CHEMBL5434414 1 5.07
CHEMBL5413820 1 5.06
CHEMBL5434519 1 5.06

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL252761 IC50 = 42.34 nM 7.37
CHEMBL5411091 IC50 = 7247.0 nM 5.14
CHEMBL5437584 IC50 = 7412.0 nM 5.13
CHEMBL5428091 IC50 = 7682.0 nM 5.12
CHEMBL5402580 IC50 = 7593.0 nM 5.12
CHEMBL5411375 IC50 = 7673.0 nM 5.12
CHEMBL5403784 IC50 = 7659.0 nM 5.12
CHEMBL5405579 IC50 = 7612.0 nM 5.12
CHEMBL5403866 IC50 = 7819.0 nM 5.11
CHEMBL5435391 IC50 = 7698.0 nM 5.11
CHEMBL5439708 IC50 = 7791.0 nM 5.11
CHEMBL5408361 IC50 = 7745.0 nM 5.11
CHEMBL5432287 IC50 = 7703.0 nM 5.11
CHEMBL5408918 IC50 = 7703.0 nM 5.11
CHEMBL5437979 IC50 = 7686.0 nM 5.11
CHEMBL5423687 IC50 = 7803.0 nM 5.11
CHEMBL5437251 IC50 = 7843.0 nM 5.11
CHEMBL5436065 IC50 = 8018.0 nM 5.10
CHEMBL5409834 IC50 = 7998.0 nM 5.10
CHEMBL5439622 IC50 = 8207.0 nM 5.09
CHEMBL5433156 IC50 = 8068.0 nM 5.09
CHEMBL5433711 IC50 = 8237.0 nM 5.08
CHEMBL5441124 IC50 = 8275.0 nM 5.08
CHEMBL5434414 IC50 = 8578.0 nM 5.07
CHEMBL5428502 IC50 = 8491.0 nM 5.07
CHEMBL5397012 IC50 = 8608.0 nM 5.07
CHEMBL5437898 IC50 = 8534.0 nM 5.07
CHEMBL5398897 IC50 = 8534.0 nM 5.07
CHEMBL5413820 IC50 = 8687.0 nM 5.06
CHEMBL5434519 IC50 = 8747.0 nM 5.06
CHEMBL5425117 IC50 = 8793.0 nM 5.06
CHEMBL5427329 IC50 = 8848.0 nM 5.05
CHEMBL5425539 IC50 = 8873.0 nM 5.05
CHEMBL5441132 IC50 = 8907.0 nM 5.05
CHEMBL5415366 IC50 = 8889.0 nM 5.05
CHEMBL5413463 IC50 = 8818.0 nM 5.05
CHEMBL5432496 IC50 = 9074.0 nM 5.04
CHEMBL5410090 IC50 = 9062.0 nM 5.04
CHEMBL5432722 IC50 = 9186.0 nM 5.04
CHEMBL5432224 IC50 = 9172.0 nM 5.04
CHEMBL5438169 IC50 = 9067.0 nM 5.04
CHEMBL5436859 IC50 = 9357.0 nM 5.03
CHEMBL5434537 IC50 = 9875.0 nM 5.00
CHEMBL5418432 IC50 > 10000.0 nM -
CHEMBL5425813 IC50 > 10000.0 nM -
CHEMBL5414065 IC50 > 10000.0 nM -
CHEMBL5407894 IC50 > 10000.0 nM -
CHEMBL5421438 IC50 > 10000.0 nM -
CHEMBL5430452 IC50 > 10000.0 nM -
CHEMBL5393904 IC50 > 10000.0 nM -