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Assay Detail

CHEMBL5320173

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of sCy5-MT-I from human MC3R stably expressed in human HEK293 cells incubated for 2 hrs by Cheng-Prusoff equation based FACS analysis
15
Total Activities
15
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type HEK293
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Melanocortin receptor 3 (CHEMBL4644)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Targeting Melanocortin Receptors Using S<sub><i>N</i></sub>Ar-Type Macrocyclization: A Doubly Orthogonal Route to Cyclic Peptide Conjugates.
Yue WK, Zhang T, Shandre Mugan R, Barlow N, Chalmers DK, Pouton CW, Thompson PE.
J Med Chem (2023) 66 : 3273 -3283
PubMed 36808973 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 14 6.85 9.03
pKi 1 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL430239 MELATONAN 1 9.03
CHEMBL5432664 1 8.10
CHEMBL5421885 1 7.10
CHEMBL5426684 1 7.01
CHEMBL5399539 1 6.88
CHEMBL5432868 1 6.83
CHEMBL5414451 1 6.76
CHEMBL5398659 1 6.58
CHEMBL504986 1 6.50
CHEMBL5421108 1 6.36
CHEMBL5405038 1 6.29
CHEMBL5438253 1 6.18
CHEMBL5413092 1 6.13
CHEMBL5438629 1 6.09
CHEMBL5416095 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL430239 MELATONAN Ki = 0.9333 nM 9.03
CHEMBL5432664 Ki = 7.943 nM 8.10
CHEMBL5421885 Ki = 79.43 nM 7.10
CHEMBL5426684 Ki = 97.72 nM 7.01
CHEMBL5399539 Ki = 131.83 nM 6.88
CHEMBL5432868 Ki = 147.91 nM 6.83
CHEMBL5414451 Ki = 173.78 nM 6.76
CHEMBL5398659 Ki = 263.03 nM 6.58
CHEMBL504986 Ki = 316.23 nM 6.50
CHEMBL5421108 Ki = 436.52 nM 6.36
CHEMBL5405038 Ki = 512.86 nM 6.29
CHEMBL5438253 Ki = 660.69 nM 6.18
CHEMBL5413092 Ki = 741.31 nM 6.13
CHEMBL5438629 Ki = 812.83 nM 6.09
CHEMBL5416095 pKi - -