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Compound Detail

CHEMBL5414451

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C[C@@H]1NC(=O)c2cc(-c3cn([C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)nn3)ccc2SC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O

Basic Information

ChEMBL ID CHEMBL5414451
Phase Preclinical
Structure Type MOL
InChI Key SSZDAFBCWHVROA-BNDGGGGKSA-N
4
Targets
8
Activities
2
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

1149.3
MW (Da)

Drug Information

Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C53H64N16O12S
MW 1149.26

Activity Summary

EC50 4 meas. best 9.87
Ki 4 meas. best 10.22

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Melanocortin receptor 4
CHEMBL259
Ki 10.22 10.205 0.1 2
Melanocortin receptor 4
CHEMBL259
EC50 9.87 9.87 0.1 1
Melanocyte-stimulating hormone receptor
CHEMBL3795
Ki 8.6 8.6 2.5 1
Melanocyte-stimulating hormone receptor
CHEMBL3795
EC50 7.78 7.78 16.6 1
Melanocortin receptor 3
CHEMBL4644
EC50 7.2 7.2 63.1 1
Melanocortin receptor 3
CHEMBL4644
Ki 6.76 6.76 173.8 1
Melanocortin receptor 5
CHEMBL4608
EC50 6.53 6.53 295.1 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
36808973 10.1021/acs.jmedchem.2c01587 Melanocortin receptor 4 3
36808973 10.1021/acs.jmedchem.2c01587 Melanocyte-stimulating hormone receptor 2
36808973 10.1021/acs.jmedchem.2c01587 Melanocortin receptor 3 2
36808973 10.1021/acs.jmedchem.2c01587 Melanocortin receptor 5 2

Data from ChEMBL 36 via Core Engine