Assay Detail
Binding
CHEMBL5320530
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Binding affinity to SARS-CoV-1 MPro assessed as inhibition constant
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Severe acute respiratory syndrome-related coronavirus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Replicase polyprotein 1ab (CHEMBL5118) ↗| Type | SINGLE PROTEIN |
| Organism | Severe acute respiratory syndrome-related coronavirus |
Publication
Antitarget, Anti-SARS-CoV-2 Leads, Drugs, and the Drug Discovery-Genetics Alliance Perspective.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 7.39 | 8.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4777223 | PF-00835231 | -1.0 | 1 | 8.31 |
| CHEMBL2435614 | — | — | 1 | 8.20 |
| CHEMBL497141 | — | — | 1 | 8.12 |
| CHEMBL213054 | — | — | 1 | 7.28 |
| CHEMBL1230135 | — | — | 1 | 5.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4777223 | PF-00835231 | Ki | = | 4.94 | nM | 8.31 |
| CHEMBL2435614 | — | Ki | = | 6.3 | nM | 8.20 |
| CHEMBL497141 | — | Ki | = | 7.5 | nM | 8.12 |
| CHEMBL213054 | — | Ki | = | 53.0 | nM | 7.28 |
| CHEMBL1230135 | — | Ki | = | 9000.0 | nM | 5.05 |