Assay Detail
Binding
CHEMBL5320534
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Inhibition of SARS-CoV-1 MPro
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Severe acute respiratory syndrome-related coronavirus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Replicase polyprotein 1ab (CHEMBL5118) ↗| Type | SINGLE PROTEIN |
| Organism | Severe acute respiratory syndrome-related coronavirus |
Publication
Antitarget, Anti-SARS-CoV-2 Leads, Drugs, and the Drug Discovery-Genetics Alliance Perspective.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.22 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4777223 | PF-00835231 | -1.0 | 1 | 8.40 |
| CHEMBL2435614 | — | — | 1 | 6.13 |
| CHEMBL5075209 | — | — | 1 | 6.05 |
| CHEMBL2442057 | — | — | 1 | 4.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4777223 | PF-00835231 | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL2435614 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL5075209 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL2442057 | — | IC50 | = | 51000.0 | nM | 4.29 |