Assay Detail
Functional
CHEMBL5320993
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Antiviral activity against HCoV-OC43 infected in human MRC5 cells assessed as reduction of virus induced cytopathic effect incubated for 5 days by Cell-titer Glo assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human coronavirus OC43 |
| Cell Type | MRC5 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of novel bicyclic[3.3.0]proline peptidyl α-ketoamides as potent 3CL-protease inhibitors for SARS-CoV-2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 6.28 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4802135 | NIRMATRELVIR | 4.0 | 1 | 7.16 |
| CHEMBL5439916 | — | — | 1 | 6.95 |
| CHEMBL5419985 | — | — | 1 | 6.87 |
| CHEMBL5403964 | — | — | 1 | 6.84 |
| CHEMBL5409804 | — | — | 1 | 6.38 |
| CHEMBL5414443 | — | — | 1 | 6.35 |
| CHEMBL5400701 | — | — | 1 | 6.24 |
| CHEMBL5402227 | — | — | 1 | 6.17 |
| CHEMBL5411271 | — | — | 1 | 5.56 |
| CHEMBL5400782 | — | — | 1 | 5.31 |
| CHEMBL5403340 | — | — | 1 | 5.24 |
| CHEMBL5430131 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4802135 | NIRMATRELVIR | EC50 | = | 70.0 | nM | 7.16 |
| CHEMBL5439916 | — | EC50 | = | 112.0 | nM | 6.95 |
| CHEMBL5419985 | — | EC50 | = | 136.0 | nM | 6.87 |
| CHEMBL5403964 | — | EC50 | = | 146.0 | nM | 6.84 |
| CHEMBL5409804 | — | EC50 | = | 421.0 | nM | 6.38 |
| CHEMBL5414443 | — | EC50 | = | 444.0 | nM | 6.35 |
| CHEMBL5400701 | — | EC50 | = | 573.0 | nM | 6.24 |
| CHEMBL5402227 | — | EC50 | = | 677.0 | nM | 6.17 |
| CHEMBL5411271 | — | EC50 | = | 2778.0 | nM | 5.56 |
| CHEMBL5400782 | — | EC50 | = | 4887.0 | nM | 5.31 |
| CHEMBL5403340 | — | EC50 | = | 5806.0 | nM | 5.24 |
| CHEMBL5430131 | — | EC50 | > | 10000.0 | nM | - |