Assay Detail
Binding
CHEMBL5324496
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Binding affinity to sigma1 receptor (unknown origin) assessed as inhibition constant
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sigma non-opioid intracellular receptor 1 (CHEMBL287) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of WLB-89462, a New Drug-like and Highly Selective σ<sub>2</sub> Receptor Ligand with Neuroprotective Properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.14 | 9.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53325 | — | — | 1 | 9.42 |
| CHEMBL61479 | SIRAMESINE | 2.0 | 1 | 7.77 |
| CHEMBL4846092 | — | — | 1 | 7.20 |
| CHEMBL5395401 | — | — | 1 | 6.28 |
| CHEMBL5426155 | — | — | 1 | 6.25 |
| CHEMBL5189158 | — | — | 1 | 5.89 |
| CHEMBL4297605 | ROLUPERIDONE | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53325 | — | Ki | = | 0.38 | nM | 9.42 |
| CHEMBL61479 | SIRAMESINE | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL4846092 | — | Ki | = | 63.0 | nM | 7.20 |
| CHEMBL5395401 | — | Ki | = | 530.0 | nM | 6.28 |
| CHEMBL5426155 | — | Ki | = | 560.0 | nM | 6.25 |
| CHEMBL5189158 | — | Ki | = | 1279.0 | nM | 5.89 |
| CHEMBL4297605 | ROLUPERIDONE | Ki | >= | 1000.0 | nM | - |