Assay Detail
ADMET
CHEMBL5325813
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CYP3A4 (unknown origin) incubated for 1 hr in presence of NADPH and 7-BFC by fluorescence based analysis
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design of Cytochrome P450 1B1 Inhibitors <i>via</i> a Scaffold-Hopping Approach.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.82 | 5.83 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5406218 | — | — | 1 | 5.83 |
| CHEMBL5406710 | — | — | 1 | 5.80 |
| CHEMBL5412548 | — | — | 1 | - |
| CHEMBL5394220 | — | — | 1 | - |
| CHEMBL5425709 | — | — | 1 | - |
| CHEMBL5401046 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5406218 | — | IC50 | = | 1490.0 | nM | 5.83 |
| CHEMBL5406710 | — | IC50 | = | 1580.0 | nM | 5.80 |
| CHEMBL5412548 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5394220 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5425709 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5401046 | — | IC50 | > | 10000.0 | nM | - |