Assay Detail
Functional
CHEMBL5327080
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Antiproliferative activity against human HT-1080 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-1080 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of ML210-Based glutathione peroxidase 4 (GPX4) degrader inducing ferroptosis of human cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.49 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5410624 | — | — | 1 | 7.00 |
| CHEMBL1951048 | — | — | 1 | 7.00 |
| CHEMBL5421807 | — | — | 1 | 6.52 |
| CHEMBL5430090 | — | — | 1 | 6.00 |
| CHEMBL5420578 | — | — | 1 | 5.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5410624 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL1951048 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL5421807 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL5430090 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL5420578 | — | IC50 | = | 1200.0 | nM | 5.92 |