Compound Detail
CHEMBL5430090
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Cc1onc(C(=O)N2CCN(C(c3ccc(Cl)cc3)c3ccc(OCC(=O)N4CCC(CN5CCC(CN6CCN(c7cccc8c7C(=O)N(C7CCC(=O)NC7=O)C8=O)CC6)CC5)CC4)cc3)CC2)c1[N+](=O)[O-]
Basic Information
| ChEMBL ID | CHEMBL5430090 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | PUWBPSLIEAYIKX-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
1033.6
MW (Da)
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| HT-1080 CHEMBL614580 | IC50 | 6.0 | 6.0 | 1000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| HT-1080 | IC50 | = | 1000.0 | nM | 6.0 | Antiproliferative activity against human HT-1080 cells assessed as reduction in ... | 37087895 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 37087895 | 10.1016/j.ejmech.2023.115343 | Protein cereblon/Phospholipid hydroperoxide glutathione peroxidase | 1 |
| 37087895 | 10.1016/j.ejmech.2023.115343 | HT-1080 | 1 |
Data from ChEMBL 36 via Core Engine