Assay Detail
Binding
CHEMBL5328237
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Negative allosteric modulator activity at human Pancreatic lipase using DDAO-ol as fluorescent substrate preincubated for 3 mins followed by substrate addition measured after 20 mins by microplate reader assay
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of salicylanilides as novel allosteric inhibitors of human pancreatic lipase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 5.20 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL175247 | ORLISTAT | 4.0 | 1 | 8.80 |
| CHEMBL164 | MYRICETIN | — | 1 | 5.87 |
| CHEMBL50 | QUERCETIN | 3.0 | 1 | 5.82 |
| CHEMBL4641560 | — | — | 1 | 5.79 |
| CHEMBL5410259 | — | — | 1 | 5.73 |
| CHEMBL1631675 | — | — | 1 | 5.67 |
| CHEMBL287542 | RAFOXANIDE | 2.0 | 1 | 5.60 |
| CHEMBL204813 | SANGGENON C | — | 1 | 5.48 |
| CHEMBL5423733 | — | — | 1 | 5.37 |
| CHEMBL5419885 | — | — | 1 | 5.22 |
| CHEMBL5413231 | — | — | 1 | 5.20 |
| CHEMBL5405185 | — | — | 1 | 5.17 |
| CHEMBL5439220 | — | — | 1 | 5.03 |
| CHEMBL5402667 | — | — | 1 | 5.00 |
| CHEMBL5399755 | — | — | 1 | 5.00 |
| CHEMBL5420710 | — | — | 1 | 4.98 |
| CHEMBL5430137 | — | — | 1 | 4.96 |
| CHEMBL5436175 | — | — | 1 | 4.95 |
| CHEMBL5396102 | — | — | 1 | 4.92 |
| CHEMBL5428235 | — | — | 1 | 4.91 |
| CHEMBL5412428 | — | — | 1 | 4.91 |
| CHEMBL5404043 | — | — | 1 | 4.82 |
| CHEMBL5409756 | — | — | 1 | 4.80 |
| CHEMBL5418104 | — | — | 1 | 4.78 |
| CHEMBL5404594 | — | — | 1 | 4.74 |
| CHEMBL5409828 | — | — | 1 | 4.72 |
| CHEMBL5432097 | — | — | 1 | 4.69 |
| CHEMBL5412841 | — | — | 1 | 4.62 |
| CHEMBL5413833 | — | — | 1 | 4.58 |
| CHEMBL5432795 | — | — | 1 | 4.56 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL175247 | ORLISTAT | IC50 | = | 1.57 | nM | 8.80 |
| CHEMBL164 | MYRICETIN | IC50 | = | 1340.0 | nM | 5.87 |
| CHEMBL50 | QUERCETIN | IC50 | = | 1530.0 | nM | 5.82 |
| CHEMBL4641560 | — | IC50 | = | 1630.0 | nM | 5.79 |
| CHEMBL5410259 | — | IC50 | = | 1860.0 | nM | 5.73 |
| CHEMBL1631675 | — | IC50 | = | 2130.0 | nM | 5.67 |
| CHEMBL287542 | RAFOXANIDE | IC50 | = | 2520.0 | nM | 5.60 |
| CHEMBL204813 | SANGGENON C | IC50 | = | 3280.0 | nM | 5.48 |
| CHEMBL5423733 | — | IC50 | = | 4270.0 | nM | 5.37 |
| CHEMBL5419885 | — | IC50 | = | 5990.0 | nM | 5.22 |
| CHEMBL5413231 | — | IC50 | = | 6270.0 | nM | 5.20 |
| CHEMBL5405185 | — | IC50 | = | 6750.0 | nM | 5.17 |
| CHEMBL5439220 | — | IC50 | = | 9240.0 | nM | 5.03 |
| CHEMBL5402667 | — | IC50 | = | 9960.0 | nM | 5.00 |
| CHEMBL5399755 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL5420710 | — | IC50 | = | 10510.0 | nM | 4.98 |
| CHEMBL5430137 | — | IC50 | = | 11020.0 | nM | 4.96 |
| CHEMBL5436175 | — | IC50 | = | 11360.0 | nM | 4.95 |
| CHEMBL5396102 | — | IC50 | = | 12040.0 | nM | 4.92 |
| CHEMBL5428235 | — | IC50 | = | 12360.0 | nM | 4.91 |
| CHEMBL5412428 | — | IC50 | = | 12380.0 | nM | 4.91 |
| CHEMBL5404043 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL5409756 | — | IC50 | = | 15750.0 | nM | 4.80 |
| CHEMBL5418104 | — | IC50 | = | 16670.0 | nM | 4.78 |
| CHEMBL5404594 | — | IC50 | = | 18270.0 | nM | 4.74 |
| CHEMBL5409828 | — | IC50 | = | 19070.0 | nM | 4.72 |
| CHEMBL5432097 | — | IC50 | = | 20410.0 | nM | 4.69 |
| CHEMBL5412841 | — | IC50 | = | 23710.0 | nM | 4.62 |
| CHEMBL5413833 | — | IC50 | = | 26320.0 | nM | 4.58 |
| CHEMBL5432795 | — | IC50 | = | 27360.0 | nM | 4.56 |
| CHEMBL5415926 | — | IC50 | = | 32660.0 | nM | 4.49 |
| CHEMBL389507 | OSALMID | IC50 | > | 500000.0 | nM | - |