Assay Detail
Binding
CHEMBL5328508
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Binding affinity to S1R (unknown origin)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sigma non-opioid intracellular receptor 1 (CHEMBL287) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of AD258 as a Sigma Receptor Ligand with Potent Antiallodynic Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 9.22 | 10.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5432062 | — | — | 1 | 10.89 |
| CHEMBL5402927 | — | — | 1 | 8.72 |
| CHEMBL39900 | SPIPETHIANE | — | 1 | 8.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5432062 | — | Ki | = | 0.013 | nM | 10.89 |
| CHEMBL5402927 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL39900 | SPIPETHIANE | Ki | = | 9.2 | nM | 8.04 |